Liesel Litzenburger's essays and stories have appeared in numerous literary journals, magazines, and anthologies. Three Rivers Press/Random House published her novel-in-stories, Now You Love Me, in February 2007. She has written and reviewed for the Chicago Tribune and the Detroit Free Press.

Litzenburger has taught writing at Central Michigan University and several other colleges and universities, including the University of Michigan, and held a position as Acting Chair of the Creative Writing Program at the Interlochen Arts Academy. She served as the 2001 Writer-in-Residence at New College of the University of South Florida, Sarasota-Manatee campus, a distinguished residential college that serves as the honors college of the State University System. She was the recipient of a 2003 Michigan Council for the Arts and Cultural Affairs Creative Artist Grant for fiction writing. Litzenburger's first novel, The Widower, was published by Shaye Areheart Books in August 2006.